ISCHeMAG

Projet ISCHeMAG
Theranostic treatment of ischemic stroke using magnetic hyperthermia
Collaborative (PRC) – Coordinateur : Damine MERTZ (IPCMS, Strasbourg) Total Budget : 619 746,00€
Consortium : IPCMS, Strasbourg – Dr Damien MERTZ (CR CNRS) LPCNO Toulouse – Dr Céline Nayral (MCU, Insa Toulouse) PhIND Caen – Dr Thomas Bonnard (CRCN Inserm) Cerebrovascular accidents or strokes are a major public health issue, currently the second leading cause of death. With the aging of the population, the occurrence is increasing and there is a significant need for more effective treatments. Although prompt treatments of strokes save the life of half of patients, the resulting brain damage often remains dramatic for survivors and stroke is the leading cause of acquired disability in adults, accounting for serious socio-economic consequences. In about 80% of cases, a stroke is caused by a blood clot (called a thrombus) which blocks the blood supply to the brain; the stroke is said to be ischemic. Current treatments consist in the administration of molecules promoting the breakdown of the clot (thrombolysis) or mechanical evacuation via a catheter (thrombectomy) but their effectiveness remains very limited. In this context, inorganic nanomaterials that can be made multifunctional, offer a panel of promising and innovative strategies for the combined diagnosis and treatment of blood clots. In this ANR-PRC project, the challenge will be the elaboration of a new treatment strategy against stroke based on smart theragnostic magnetically responsive nanoengineered inorganic nanoparticles (Figure 1). We will design core@shell nano-objects having an iron oxide core (denoted IO, size ca. 20 nm) covered with stellate mesoporous silica (denoted STMS) tailored with adjustable thickness and pores size, denoted IO@STMSx (x stands for tuning silica structure). The magnetic core will ensure localized hyperthermia effect under radiofrequency alternating magnetic field (AMF) and also the T2-weighted magnetic resonance imaging (MRI) of the thrombose evolution. Moreover, the porous silica shell will bring additional key features (such as local delivery of thrombolytic and anti-oxidant agents) aiming at boosting the treatment effect (details as follows).
Collaborative (PRC) – Coordinateur : Damine MERTZ (IPCMS, Strasbourg) Total Budget : 619 746,00€
Consortium : IPCMS, Strasbourg – Dr Damien MERTZ (CR CNRS) LPCNO Toulouse – Dr Céline Nayral (MCU, Insa Toulouse) PhIND Caen – Dr Thomas Bonnard (CRCN Inserm)