We have studied the functional repercussions of cerebrovascular abnormalities in transgenic mice overexpressing TGF-beta1. These mice develop Alzheimer’s disease-like vascular (…)
Consulter 
2005
Accumulating evidence demonstrates a critical involvement of tissue-type plasminogen activator (tPA) in pathological and physiological brain conditions. Determining whether and (…)
Consulter
2005
Smad2 and Smad3 (Smad2/3) proteins are key signaling molecules for TGF-beta and some related family members regulating the transcription of (…)
Consulter
2005
Considering its brain-specific expression, neuroserpin (NS), a potent inhibitor of tissue-type plasminogen activator (tPA), might be a good therapeutic target (…)
Consulter
2005
Acute brain injuries have been identified as a risk factor for developing Alzheimer’s disease (AD). Because glutamate plays a pivotal (…)
Consulter
Transforming growth factor-beta (TGF-beta) has been characterized as an injury-related factor, based on the observation that it is strongly up-regulated (…)
Consulter
